Renal failure is also frequently associated with gouty nephropathy and rarely with hypersensitivity reactions associated with Allopurinol. The updated prescribing information is expected to be implemented in early May, the company said. Before taking allopurinol, tell your doctor if you are allergic to any drugs, or if you have: kidney liver congestive heart high blood or if you are receiving any chemotherapy. Allopurinol is indicated in: the management of patients with signs and symptoms of primary or secondary gout acute attacks, tophi, joint destruction, uric acid lithiasis, and allopurinol online jotta or nephropathy. Two of the patients had Lesch-Nyhan syndrome, which is characterized by excessive uric acid production combined with deficiency of the enzyme, hypoxanthineguanine phosphoribosyltransferase HGPRTase. Bone marrow depression has been reported in patients receiving Allopurinol, most of whom received concomitant drugs with the potential for causing this reaction.