Symptoms of overdose may include: bloody diarrhea, blood in the urine, change in the amount of urine, muscle weakness, seizures, confusion. Why It Is Used Colchicine has long been used to relieve acute gout attacks. Last updated on RxList: 12 2004 SIDE EFFECTS Adverse reactions in decreasing order of severity are: bone marrow depression, with aplastic anemia, with agranulocytosis or with thrombocytopenia may occur in patients receiving long-term therapy. The number colchicine kjop of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on how often your attacks occur and on whether you are taking the medicine to prevent or to relieve attacks. Finding these side effects early can help to keep them from becoming serious. There is no specific antidote for colchicine, although various treatments do exist.